New Gene Therapy Vector—Nano-Hydroxyapatite

New hopes for gene therapy

Hopes were running high at the end of the 20th century. The newly hatched internet economy took off, the Cold War was consigned to history, two separate teams were racing to sequence the human genome, and once that was in the databanks, surely we would understand much more about our diseases and develop new cures based on the genetic insights. And Al Gore might become US president and do someth...

ژن درمانی Gene Therapy

New frontiers in transfusion medicine: gene therapy

Techniques of separation, purification as well as cryopreservation of marrow, blood, cord blood or tissue cells have been developed in blood banks. Transfusion medicine, over the last 20 years, has advanced radically from total blood transfusion to cell and ex vivo gene therapy, going through different stages, including the production of well-defined cell products (red blood cells, platelets, g...

Nano-Hydroxyapatite-Derived Drug and Gene Co-Delivery System for Anti-Angiogenesis Therapy of Breast Cancer

BACKGROUND Breast cancer is among the deadliest cancers across the world and is responsible for countless deaths. There is an urgent need for co-delivery systems which can simultaneously transport both drug and gene into a single cancer cell with low toxicity and high anti-angiogenesis efficiency. MATERIAL AND METHODS In the present study, well-formed amine-functionalized hydroxyapatite nanopar...

Polystyrene-Hydroxyapatite Nanocomposite as a New Adsorbent of Aflatoxin M1

Background & Aims: Aflatoxin M1 is one of the most important toxins present in milk and the product of aflatoxin B1 metabolism in liver microsomes. The aim of this project was to study the aflatoxin M1 adsorption ability of polystyrene-hydroxyapatite nanocomposite. Methods: First, the probability of aflatoxin M1 adsorption by the nanocomposite was evaluated using the HyperChem simulation softwa...